منابع مشابه
Pancreatic function in carboxyl-ester lipase knockout mice.
BACKGROUND/AIMS CEL-MODY is a monogenic form of diabetes and exocrine pancreatic insufficiency due to mutations in the carboxyl-ester lipase (CEL) gene. We aimed to investigate endocrine and exocrine pancreatic function in CEL knockout mice (CELKO). METHODS A knockout mouse model with global targeted deletion of CEL was investigated physiologically and histopathologically, and compared to lit...
متن کاملChromosomal localization of lipolytic enzymes in the mouse: pancreatic lipase, colipase, hormone-sensitive lipase, hepatic lipase, and carboxyl ester lipase.
Several lipases and their cofactors are involved in the absorption, transport, storage, and mobilization of lipids. As part of an effort to examine the role of these enzymes in plasma lipid metabolism and genetic susceptibility to atherosclerosis, we report the chromosomal mapping of their genes in mouse. Restriction fragment length variants for each gene were identified, typed in an interspeci...
متن کاملTranscriptional Regulation of the Human Carboxyl Ester Lipase Gene in Exocrine Pancreas
The human carboxyl ester lipase (CEL) is an important enzyme for the intestinal absorption of dietary lipids. The gene is highly expressed in exocrine pancreas and in the mammary gland during pregnancy and lactation. In this paper, we have focused on its transcriptional regulation in exocrine pancreas. Reporter gene analysis in cell cultures reveals that a high level of tissue-specific expressi...
متن کاملThe expression of the carboxyl ester lipase gene in pancreas and pancreatic adenocarcinomas.
Since pancreatic cancer is an aggressive and often incurable malignancy, we investigated if the carboxyl ester lipase gene (CEL) is specifically expressed in pancreatic tissues and its promoter can be used for a specific suicide gene approach. Twenty-five tumor samples, 24 samples of normal pancreatic tissue and control tissues from other organs were examined by radioactive in situ hybridizatio...
متن کاملCarboxyl ester lipase activity in milk prevents fat-derived intestinal injury in neonatal mice.
Carboxyl ester lipase (bile salt-stimulated lipase) is a pancreatic enzyme capable of hydrolyzing esters of cholesterol and fat-soluble vitamins. It also efficiently digests triglycerides (TG) into free fatty acids and glycerol and is abundant in the milk of humans and several other species. We used the mouse as a model to test the hypothesis that milk-derived carboxyl ester lipase (CEL) digest...
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ژورنال
عنوان ژورنال: Journal of Lipid Research
سال: 2002
ISSN: 0022-2275
DOI: 10.1194/jlr.r200013-jlr200